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Gene: SIGMAR1 (sigma non-opioid intracellular receptor 1) Homo sapiens
Symbol: SIGMAR1
Name: sigma non-opioid intracellular receptor 1
Description: Exhibits identical protein binding activity. Involved in protein homotrimerization and regulation of neuron apoptotic process. Localizes to several cellular components, including the endoplasmic reticulum; nuclear envelope; and postsynaptic density. Implicated in amyotrophic lateral sclerosis type 16 and distal spinal muscular atrophy 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aging-associated gene 8 protein; ALS16; DSMA2; FLJ25585; hSigmaR1; MGC3851; opioid receptor, sigma 1; OPRS1; SIG-1R; sigma 1-type opioid receptor; sigma1 receptor; sigma1-receptor; sigma1R; SR-BP; SR-BP1; SR31747 binding protein 1; SR31747-binding protein; SRBP; type I sigma receptor
Mus musculus (house mouse) : Sigmar1 (sigma non-opioid intracellular receptor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sigmar1 (sigma non-opioid intracellular receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sigmar1 (sigma non-opioid intracellular receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIGMAR1 (sigma non-opioid intracellular receptor 1)
Canis lupus familiaris (dog) : SIGMAR1 (sigma non-opioid intracellular receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sigmar1 (sigma non-opioid intracellular receptor 1)
Sus scrofa (pig) : SIGMAR1 (sigma non-opioid intracellular receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38934,634,722 - 34,637,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37934,634,719 - 34,637,805 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,624,719 - 34,627,768 (-)NCBINCBI36hg18NCBI36
Build 34934,624,719 - 34,627,768NCBI
Celera934,566,222 - 34,569,271 (-)NCBI
Cytogenetic Map9p13.3NCBI
HuRef934,589,001 - 34,592,050 (-)NCBIHuRef
CHM1_1934,634,494 - 34,637,593 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SIGMAR1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68519
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.