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Gene: TDO2 (tryptophan 2,3-dioxygenase) Homo sapiens
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Symbol: TDO2
Name: tryptophan 2,3-dioxygenase
Description: Exhibits heme binding activity; identical protein binding activity; and tryptophan 2,3-dioxygenase activity. Involved in protein homotetramerization and tryptophan catabolic process to kynurenine. Predicted to localize to the cytosol. Implicated in Gilles de la Tourette syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HYPTRP; TDO; TO; TPH2; TRPO; tryptamin 2,3-dioxygenase; tryptophan oxygenase; tryptophan pyrrolase; tryptophanase
Orthologs:
Mus musculus (house mouse) : Tdo2 (tryptophan 2,3-dioxygenase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tdo2 (tryptophan 2,3-dioxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tdo2 (tryptophan 2,3-dioxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : TDO2 (tryptophan 2,3-dioxygenase)
Canis lupus familiaris (dog) : TDO2 (tryptophan 2,3-dioxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tdo2 (tryptophan 2,3-dioxygenase)
Sus scrofa (pig) : TDO2 (tryptophan 2,3-dioxygenase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl4155,854,738 - 155,920,406 (+)Ensembl
GRCh384155,903,696 - 155,920,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374156,824,845 - 156,841,558 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364157,044,297 - 157,061,000 (+)NCBINCBI36hg18NCBI36
Build 344157,182,451 - 157,199,155NCBI
Celera4154,156,425 - 154,173,133 (+)NCBI
Cytogenetic Map4q32.1NCBI
HuRef4152,563,673 - 152,580,472 (+)NCBIHuRef
CHM1_14156,802,468 - 156,819,210 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TDO2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68531
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.