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Gene: Tdo2 (tryptophan 2,3-dioxygenase) Mus musculus
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Symbol: Tdo2
Name: tryptophan 2,3-dioxygenase
Description: Predicted to have several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Predicted to be involved in protein homotetramerization; tryptophan catabolic process to acetyl-CoA; and tryptophan catabolic process to kynurenine. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome. Is expressed in cerebellum and liver. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase); PARTICIPATES IN kynurenine metabolic pathway; tryptophan metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AA407491; chky; TDO; tdo variant1; tdo variant2; TO; TRPO; tryptamin 2,3-dioxygenase; tryptophan oxygenase; tryptophan pyrrolase; tryptophan-2,3-dioxygenase; tryptophanase
Orthologs:
Homo sapiens (human) : TDO2 (tryptophan 2,3-dioxygenase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tdo2 (tryptophan 2,3-dioxygenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tdo2 (tryptophan 2,3-dioxygenase)
Pan paniscus (bonobo/pygmy chimpanzee) : TDO2 (tryptophan 2,3-dioxygenase)
Canis lupus familiaris (dog) : TDO2 (tryptophan 2,3-dioxygenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tdo2 (tryptophan 2,3-dioxygenase)
Sus scrofa (pig) : TDO2 (tryptophan 2,3-dioxygenase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl381,957,090 - 81,976,202 (-)Ensembl
GRCm38381,958,412 - 81,975,728 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37381,762,334 - 81,779,650 (-)NCBIGRCm37mm9NCBIm37
MGSCv36382,044,339 - 82,061,655 (-)NCBImm8
Celera381,983,687 - 82,001,014 (-)NCBICelera
Cytogenetic Map3 E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tdo2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68532
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.