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Gene: Mtor (mechanistic target of rapamycin kinase) Mus musculus
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Symbol: Mtor
Name: mechanistic target of rapamycin kinase
Description: Exhibits protein serine/threonine kinase activity and ribosome binding activity. Involved in several processes, including heart development; positive regulation of cellular component organization; and protein phosphorylation. Localizes to several cellular components, including the TORC1 complex; cytosol; and dendrite. Colocalizes with the PML body. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Is expressed in central nervous system; early conceptus; respiratory system; and retina. Orthologous to human MTOR (mechanistic target of rapamycin kinase); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-4 signaling pathway; mTOR signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610315D21Rik; AI327068; angiopoietin-like factor CDT6; FK506 binding protein 12-rapamycin associated protein 1; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP-rapamycin associated protein (FRAP); FKBP-rapamycin-associated protein FRAP; FKBP12-rapamycin complex-associated protein; flat; FRAP; Frap1; FRAP2; mammalian target of rapamycin; mechanistic target of rapamycin (serine/threonine kinase); MGC118056; RAFT1; rapamycin target protein 1; RAPT1; serine/threonine-protein kinase mTOR
Orthologs:
Homo sapiens (human) : MTOR (mechanistic target of rapamycin kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mtor (mechanistic target of rapamycin kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mtor (mechanistic target of rapamycin kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MTOR (mechanistic target of rapamycin kinase)
Canis lupus familiaris (dog) : MTOR (mechanistic target of rapamycin kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mtor (mechanistic target of rapamycin kinase)
Sus scrofa (pig) : MTOR (mechanistic target of rapamycin kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm384148,448,582 - 148,557,685 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374147,822,691 - 147,931,794 (+)NCBIGRCm37mm9NCBIm37
MGSCv364147,292,407 - 147,401,483 (+)NCBImm8
Celera4150,709,332 - 150,819,308 (+)NCBICelera
Cytogenetic Map4 E2NCBI
cM Map478.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on Mtor
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68534
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.