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Gene: EPHA3 (EPH receptor A3) Homo sapiens
Symbol: EPHA3
Name: EPH receptor A3
Description: Exhibits GPI-linked ephrin receptor activity. Involved in several processes, including cellular response to retinoic acid; ephrin receptor signaling pathway; and regulation of cytoskeleton organization. Localizes to several cellular components, including actin cytoskeleton; early endosome; and nucleus. Implicated in pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EK4; EPH-like kinase 4; eph-like tyrosine kinase 1; ephrin type-A receptor 3; ETK; ETK1; HEK; HEK4; human embryo kinase 1; testicular tissue protein Li 64; TYRO4; TYRO4 protein tyrosine kinase; tyrosine-protein kinase receptor ETK1; tyrosine-protein kinase TYRO4
Mus musculus (house mouse) : Epha3 (Eph receptor A3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Epha3 (Eph receptor A3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Epha3 (EPH receptor A3)
Pan paniscus (bonobo/pygmy chimpanzee) : EPHA3 (EPH receptor A3)
Canis lupus familiaris (dog) : EPHA3 (EPH receptor A3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Epha3 (EPH receptor A3)
Sus scrofa (pig) : EPHA3 (EPH receptor A3)
Chlorocebus sabaeus (African green monkey) : EPHA3 (EPH receptor A3)
Heterocephalus glaber (naked mole-rat) : Epha3 (EPH receptor A3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl389,107,621 - 89,482,134 (+)EnsemblGRCh38hg38GRCh38
GRCh38389,107,621 - 89,482,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37389,156,674 - 89,531,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36389,239,364 - 89,613,974 (+)NCBINCBI36hg18NCBI36
Build 34389,239,501 - 89,532,185NCBI
Celera389,910,744 - 90,285,017 (+)NCBI
Cytogenetic Map3p11.1NCBI
HuRef389,169,906 - 89,544,877 (+)NCBIHuRef
CHM1_1389,109,505 - 89,484,203 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on EPHA3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68566
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.