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Gene: ALAS1 (5'-aminolevulinate synthase 1) Homo sapiens
Symbol: ALAS1
Name: 5'-aminolevulinate synthase 1
Description: Exhibits identical protein binding activity. Predicted to be involved in heme biosynthetic process; mitochondrion organization; and regulation of lipid metabolic process. Localizes to the cytosol; mitochondrion; and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALAS; ALAS-H; ALAS3; ALASH; aminolevulinate, delta-, synthase 1; delta-ALA synthase 1; delta-aminolevulinate synthase 1; MIG4; migration-inducing protein 4
Mus musculus (house mouse) : Alas1 (aminolevulinic acid synthase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Alas1 (5'-aminolevulinate synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alas1 (5'-aminolevulinate synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ALAS1 (5'-aminolevulinate synthase 1)
Canis lupus familiaris (dog) : ALAS1 (5'-aminolevulinate synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alas1 (5'-aminolevulinate synthase 1)
Sus scrofa (pig) : ALAS1 (aminolevulinate, delta-, synthase 1 pseudogene)
Chlorocebus sabaeus (green monkey) : ALAS1 (5'-aminolevulinate synthase 1)
Heterocephalus glaber (naked mole-rat) : Alas1 (5'-aminolevulinate synthase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl352,198,086 - 52,214,327 (+)Ensembl
GRCh38352,198,083 - 52,214,327 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37352,232,099 - 52,248,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,207,156 - 52,223,383 (+)NCBINCBI36hg18NCBI36
Build 34352,207,155 - 52,223,383NCBI
Celera352,211,428 - 52,227,655 (+)NCBI
Cytogenetic Map3p21.2NCBI
HuRef352,294,291 - 52,310,540 (+)NCBIHuRef
CHM1_1352,184,622 - 52,200,871 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ALAS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68572
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.