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Gene: SH2B3 (SH2B adaptor protein 3) Homo sapiens
Symbol: SH2B3
Name: SH2B adaptor protein 3
Description: Predicted to have SH3/SH2 adaptor activity; stem cell factor receptor binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including erythrocyte development; negative regulation of receptor signaling pathway via JAK-STAT; and thrombopoietin-mediated signaling pathway. Predicted to localize to plasma membrane. Implicated in essential thrombocythemia; familial erythrocytosis 1; and myelofibrosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IDDM20; LNK; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
Mus musculus (house mouse) : Sh2b3 (SH2B adaptor protein 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sh2b3 (SH2B adaptor protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b3 (SH2B adaptor protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B3 (SH2B adaptor protein 3)
Canis lupus familiaris (dog) : SH2B3 (SH2B adaptor protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b3 (SH2B adaptor protein 3)
Sus scrofa (pig) : SH2B3 (SH2B adaptor protein 3)
Chlorocebus sabaeus (African green monkey) : SH2B3 (SH2B adaptor protein 3)
Heterocephalus glaber (naked mole-rat) : Sh2b3 (SH2B adaptor protein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl12111,405,923 - 111,451,623 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl12111,405,948 - 111,451,623 (+)EnsemblGRCh38hg38GRCh38
GRCh3812111,405,107 - 111,451,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712111,843,720 - 111,889,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,328,135 - 110,373,810 (+)NCBINCBI36hg18NCBI36
Build 3412110,306,471 - 110,352,146NCBI
Celera12111,470,186 - 111,515,861 (+)NCBI
Cytogenetic Map12q24.12NCBI
HuRef12108,858,506 - 108,903,968 (+)NCBIHuRef
CHM1_112111,811,712 - 111,857,391 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on SH2B3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68607
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.