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Gene: Sh2b3 (SH2B adaptor protein 3) Mus musculus
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Symbol: Sh2b3
Name: SH2B adaptor protein 3
Description: Exhibits SH3/SH2 adaptor activity; protein tyrosine kinase binding activity; and stem cell factor receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; myeloid cell homeostasis; and negative regulation of signal transduction. Predicted to localize to the plasma membrane. Used to study chronic myeloid leukemia. Human ortholog(s) of this gene implicated in essential thrombocythemia; familial erythrocytosis 1; and myelofibrosis. Is expressed in dorsal aorta; liver; lower jaw molar; and upper jaw molar. Orthologous to human SH2B3 (SH2B adaptor protein 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI429800; linker of T-cell receptor pathways; Lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
Orthologs:
Homo sapiens (human) : SH2B3 (SH2B adaptor protein 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sh2b3 (SH2B adaptor protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b3 (SH2B adaptor protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B3 (SH2B adaptor protein 3)
Canis lupus familiaris (dog) : SH2B3 (SH2B adaptor protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b3 (SH2B adaptor protein 3)
Sus scrofa (pig) : SH2B3 (SH2B adaptor protein 3)
Chlorocebus sabaeus (African green monkey) : SH2B3 (SH2B adaptor protein 3)
Heterocephalus glaber (naked mole-rat) : Sh2b3 (SH2B adaptor protein 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5121,815,488 - 121,837,646 (-)EnsemblGRCm38mm10GRCm38
GRCm385121,815,481 - 121,837,645 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375122,267,224 - 122,286,810 (-)NCBIGRCm37mm9NCBIm37
MGSCv365122,077,832 - 122,097,418 (-)NCBImm8
Celera5118,907,377 - 118,942,299 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Sh2b3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68608
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.