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Gene: Sh2b3 (SH2B adaptor protein 3) Mus musculus
Symbol: Sh2b3
Name: SH2B adaptor protein 3
Description: Exhibits SH3/SH2 adaptor activity; protein tyrosine kinase binding activity; and stem cell factor receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; myeloid cell homeostasis; and negative regulation of signal transduction. Predicted to localize to the plasma membrane. Used to study chronic myeloid leukemia. Human ortholog(s) of this gene implicated in essential thrombocythemia; familial erythrocytosis 1; and myelofibrosis. Is expressed in dorsal aorta; liver; lower jaw molar; and upper jaw molar. Orthologous to human SH2B3 (SH2B adaptor protein 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI429800; linker of T-cell receptor pathways; Lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
Homo sapiens (human) : SH2B3 (SH2B adaptor protein 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sh2b3 (SH2B adaptor protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b3 (SH2B adaptor protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B3 (SH2B adaptor protein 3)
Canis lupus familiaris (dog) : SH2B3 (SH2B adaptor protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b3 (SH2B adaptor protein 3)
Sus scrofa (pig) : SH2B3 (SH2B adaptor protein 3)
Chlorocebus sabaeus (African green monkey) : SH2B3 (SH2B adaptor protein 3)
Heterocephalus glaber (naked mole-rat) : Sh2b3 (SH2B adaptor protein 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl5121,815,488 - 121,837,646 (-)EnsemblGRCm38mm10GRCm38
GRCm385121,815,481 - 121,837,645 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375122,267,224 - 122,286,810 (-)NCBIGRCm37mm9NCBIm37
MGSCv365122,077,832 - 122,097,418 (-)NCBImm8
Celera5118,907,377 - 118,942,299 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sh2b3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68608
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.