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Gene: DIO3 (iodothyronine deiodinase 3) Homo sapiens
Symbol: DIO3
Name: iodothyronine deiodinase 3
Description: Predicted to have thyroxine 5'-deiodinase activity. Predicted to be involved in thyroid hormone metabolic process. Predicted to localize to the plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5DIII; D3; deiodinase, iodothyronine type III; deiodinase, iodothyronine, type III; DIOIII; iodothyronine deiodinase, placental type; thyroxine 5-deiodinase; thyroxine deiodinase type III (selenoprotein); TXDI3; type 3 DI; type 3 iodothyronine selenodeiodinase; type III iodothyronine deiodinase; type-III 5' deiodinase; type-III 5'-deiodinase
Mus musculus (house mouse) : Dio3 (deiodinase, iodothyronine type III)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dio3 (iodothyronine deiodinase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dio3 (iodothyronine deiodinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DIO3 (iodothyronine deiodinase 3)
Canis lupus familiaris (dog) : DIO3 (iodothyronine deiodinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dio3 (iodothyronine deiodinase 3)
Sus scrofa (pig) : DIO3 (iodothyronine deiodinase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl14101,561,351 - 101,563,452 (+)Ensembl
GRCh3814101,561,351 - 101,563,452 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714102,027,688 - 102,029,789 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614101,097,441 - 101,099,542 (+)NCBINCBI36hg18NCBI36
Build 3414101,097,440 - 101,099,540NCBI
Celera1482,082,777 - 82,084,878 (+)NCBI
Cytogenetic Map14q32.31NCBI
HuRef1482,210,257 - 82,212,139 (+)NCBIHuRef
CHM1_114101,966,169 - 101,968,270 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DIO3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68623
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.