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Gene: DLG3 (discs large MAGUK scaffold protein 3) Homo sapiens
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Symbol: DLG3
Name: discs large MAGUK scaffold protein 3
Description: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: discs large homolog 3; discs, large homolog 3; discs, large homolog 3 (neuroendocrine-dlg, Drosophila); disks large homolog 3; KIAA1232; MRX; MRX90; NE-Dlg; NEDLG; neuroendocrine-DLG; PPP1R82; SAP-102; SAP102; synapse-associated protein 102; XLMR
Orthologs:
Mus musculus (house mouse) : Dlg3 (discs large MAGUK scaffold protein 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dlg3 (discs large MAGUK scaffold protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg3 (discs large MAGUK scaffold protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG3 (discs large MAGUK scaffold protein 3)
Canis lupus familiaris (dog) : DLG3 (discs large MAGUK scaffold protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg3 (discs large MAGUK scaffold protein 3)
Sus scrofa (pig) : DLG3 (discs large MAGUK scaffold protein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,444,850 - 70,505,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X69,664,705 - 69,725,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,581,449 - 69,642,062 (+)NCBINCBI36hg18NCBI36
Build 34X69,447,839 - 69,505,554NCBI
CeleraX70,018,031 - 70,078,673 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX63,486,322 - 63,547,144 (+)NCBIHuRef
CHM1_1X69,558,605 - 69,619,214 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DLG3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68628
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.