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Gene: DLG3 (discs large MAGUK scaffold protein 3) Homo sapiens
Symbol: DLG3
Name: discs large MAGUK scaffold protein 3
Description: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: discs large homolog 3; discs, large homolog 3; discs, large homolog 3 (neuroendocrine-dlg, Drosophila); disks large homolog 3; KIAA1232; MRX; MRX90; NE-Dlg; NEDLG; neuroendocrine-DLG; PPP1R82; SAP-102; SAP102; synapse-associated protein 102; XLMR
Mus musculus (house mouse) : Dlg3 (discs large MAGUK scaffold protein 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dlg3 (discs large MAGUK scaffold protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg3 (discs large MAGUK scaffold protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG3 (discs large MAGUK scaffold protein 3)
Canis lupus familiaris (dog) : DLG3 (discs large MAGUK scaffold protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg3 (discs large MAGUK scaffold protein 3)
Sus scrofa (pig) : DLG3 (discs large MAGUK scaffold protein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X70,444,850 - 70,505,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X69,664,705 - 69,725,343 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,581,449 - 69,642,062 (+)NCBINCBI36hg18NCBI36
Build 34X69,447,839 - 69,505,554NCBI
CeleraX70,018,031 - 70,078,673 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX63,486,322 - 63,547,144 (+)NCBIHuRef
CHM1_1X69,558,605 - 69,619,214 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DLG3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68628
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.