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Gene: Dlg3 (discs large MAGUK scaffold protein 3) Mus musculus
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Symbol: Dlg3
Name: discs large MAGUK scaffold protein 3
Description: Exhibits ubiquitin protein ligase binding activity. Involved in establishment of planar polarity; establishment or maintenance of epithelial cell apical/basal polarity; and regulation of postsynaptic membrane neurotransmitter receptor levels. Localizes to several cellular components, including the AMPA glutamate receptor complex; bicellular tight junction; and glutamatergic synapse. Predicted to colocalize with the ionotropic glutamate receptor complex. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in central nervous system and retina. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3); INTERACTS WITH 4,4'-diaminodiphenylmethane; 4-hydroxyphenyl retinamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: discs large homolog 3; discs, large homolog 3; discs, large homolog 3 (Drosophila); disks large homolog 3; Dlgh3; mKIAA1232; SAP-102; SAP102; synapse-associated protein 102
Orthologs:
Homo sapiens (human) : DLG3 (discs large MAGUK scaffold protein 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlg3 (discs large MAGUK scaffold protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg3 (discs large MAGUK scaffold protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG3 (discs large MAGUK scaffold protein 3)
Canis lupus familiaris (dog) : DLG3 (discs large MAGUK scaffold protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg3 (discs large MAGUK scaffold protein 3)
Sus scrofa (pig) : DLG3 (discs large MAGUK scaffold protein 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38X100,767,411 - 100,818,410 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X97,963,062 - 98,013,749 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X96,970,466 - 97,021,127 (+)NCBImm8
CeleraX87,686,890 - 87,737,556 (+)NCBICelera
Cytogenetic MapX C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Dlg3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68629
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.