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Gene: DLG4 (discs large MAGUK scaffold protein 4) Homo sapiens
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Symbol: DLG4
Name: discs large MAGUK scaffold protein 4
Description: Exhibits kinase binding activity and protein C-terminus binding activity. Involved in establishment of protein localization; protein localization to synapse; and protein-containing complex assembly. Localizes to the cortical cytoskeleton and postsynaptic membrane. Predicted to colocalize with the ionotropic glutamate receptor complex and voltage-gated potassium channel complex. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: discs large homolog 4; discs, large homolog 4; disks large homolog 4; FLJ97752; FLJ98574; post-synaptic density protein 95; postsynaptic density protein 95; PSD95; SAP-90; SAP90; synapse-associated protein 90; Tax interaction protein 15
Orthologs:
Mus musculus (house mouse) : Dlg4 (discs large MAGUK scaffold protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dlg4 (discs large MAGUK scaffold protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg4 (discs large MAGUK scaffold protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG4 (discs large MAGUK scaffold protein 4)
Canis lupus familiaris (dog) : DLG4 (discs large MAGUK scaffold protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg4 (discs large MAGUK scaffold protein 4)
Sus scrofa (pig) : DLG4 (discs large MAGUK scaffold protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,187,180 - 7,220,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,093,209 - 7,123,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,033,933 - 7,063,781 (-)NCBINCBI36hg18NCBI36
Build 34177,033,935 - 7,063,745NCBI
Celera177,117,875 - 7,148,003 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef176,984,911 - 7,015,359 (-)NCBIHuRef
CHM1_1177,102,006 - 7,132,134 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on DLG4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68630
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.