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Gene: DLG4 (discs large MAGUK scaffold protein 4) Homo sapiens
Symbol: DLG4
Name: discs large MAGUK scaffold protein 4
Description: Exhibits kinase binding activity and protein C-terminus binding activity. Involved in establishment of protein localization; protein localization to synapse; and protein-containing complex assembly. Localizes to the cortical cytoskeleton and postsynaptic membrane. Predicted to colocalize with the ionotropic glutamate receptor complex and voltage-gated potassium channel complex. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: discs large homolog 4; discs, large homolog 4; disks large homolog 4; FLJ97752; FLJ98574; post-synaptic density protein 95; postsynaptic density protein 95; PSD95; SAP-90; SAP90; synapse-associated protein 90; Tax interaction protein 15
Mus musculus (house mouse) : Dlg4 (discs large MAGUK scaffold protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dlg4 (discs large MAGUK scaffold protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg4 (discs large MAGUK scaffold protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG4 (discs large MAGUK scaffold protein 4)
Canis lupus familiaris (dog) : DLG4 (discs large MAGUK scaffold protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg4 (discs large MAGUK scaffold protein 4)
Sus scrofa (pig) : DLG4 (discs large MAGUK scaffold protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38177,187,180 - 7,220,050 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,093,209 - 7,123,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,033,933 - 7,063,781 (-)NCBINCBI36hg18NCBI36
Build 34177,033,935 - 7,063,745NCBI
Celera177,117,875 - 7,148,003 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef176,984,911 - 7,015,359 (-)NCBIHuRef
CHM1_1177,102,006 - 7,132,134 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DLG4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68630
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.