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Gene: Dlg4 (discs large MAGUK scaffold protein 4) Mus musculus
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Symbol: Dlg4
Name: discs large MAGUK scaffold protein 4
Description: Exhibits ionotropic glutamate receptor binding activity and scaffold protein binding activity. Involved in several processes, including dendritic spine morphogenesis; locomotory exploration behavior; and regulation of grooming behavior. Localizes to several cellular components, including AMPA glutamate receptor complex; axon; and extrinsic component of cytoplasmic side of plasma membrane. Colocalizes with ionotropic glutamate receptor complex and postsynaptic membrane. Is expressed in central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Used to study Williams-Beuren syndrome and autism spectrum disorder. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human DLG4 (discs large MAGUK scaffold protein 4); PARTICIPATES IN glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: discs large homolog 4; discs, large homolog 4; discs, large homolog 4 (Drosophila); disks large homolog 4; Dlgh4; postsynaptic density protein 95; PSD-95; PSD-95 alpha 2b; PSD-95 beta; PSD95; SAP-90; SAP90; SAP90A; synapse-associated protein 90
Orthologs:
Homo sapiens (human) : DLG4 (discs large MAGUK scaffold protein 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dlg4 (discs large MAGUK scaffold protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dlg4 (discs large MAGUK scaffold protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : DLG4 (discs large MAGUK scaffold protein 4)
Canis lupus familiaris (dog) : DLG4 (discs large MAGUK scaffold protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dlg4 (discs large MAGUK scaffold protein 4)
Sus scrofa (pig) : DLG4 (discs large MAGUK scaffold protein 4)
Chlorocebus sabaeus (African green monkey) : DLG4 (discs large MAGUK scaffold protein 4)
Heterocephalus glaber (naked mole-rat) : Dlg4 (discs large MAGUK scaffold protein 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1170,016,942 - 70,047,522 (+)EnsemblGRCm38mm10GRCm38
GRCm381170,017,203 - 70,045,535 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371169,832,107 - 69,859,034 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,835,059 - 69,860,963 (+)NCBImm8
Celera1177,566,529 - 77,594,216 (+)NCBICelera
Cytogenetic Map11B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Dlg4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68631
Created: 2001-07-11
Species: Mus musculus
Last Modified: 2020-07-21
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.