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Gene: CLDN5 (claudin 5) Homo sapiens
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Symbol: CLDN5
Name: claudin 5
Description: Predicted to have identical protein binding activity. Involved in several processes, including establishment of blood-retinal barrier; maintenance of permeability of blood-brain barrier; and regulation of gene expression. Localizes to the apicolateral plasma membrane and bicellular tight junction. Colocalizes with the cortical actin cytoskeleton. Implicated in schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: androgen withdrawal and apoptosis induced protein RVP1-like; AWAL; BEC1; claudin-5; CPETRL1; TMDVCF; TMVCF; transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome
Orthologs:
Mus musculus (house mouse) : Cldn5 (claudin 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cldn5 (claudin 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cldn5 (claudin 5)
Pan paniscus (bonobo/pygmy chimpanzee) : CLDN5 (claudin 5)
Canis lupus familiaris (dog) : CLDN5 (claudin 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cldn5 (claudin 5)
Sus scrofa (pig) : CLDN5 (claudin 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382219,523,024 - 19,525,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,510,547 - 19,515,068 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,890,550 - 17,892,860 (-)NCBINCBI36hg18NCBI36
Build 342217,885,103 - 17,887,414NCBI
Celera223,362,807 - 3,365,120 (-)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,131,378 - 3,133,692 (-)NCBIHuRef
CHM1_12219,510,114 - 19,512,427 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CLDN5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68644
Created: 2001-07-11
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.