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Gene: Slc4a4 (solute carrier family 4 member 4) Rattus norvegicus
Symbol: Slc4a4
Name: solute carrier family 4 member 4
Description: Predicted to have identical protein binding activity and sodium:bicarbonate symporter activity. Predicted to be involved in several processes, including bicarbonate transport; positive regulation of glycolytic process; and sodium ion export across plasma membrane. Localizes to membrane. Used to study nephrogenic diabetes insipidus. Biomarker of hypertension. Human ortholog(s) of this gene implicated in renal tubular acidosis. Orthologous to human SLC4A4 (solute carrier family 4 member 4); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: electrogenic sodium bicarbonate cotransporter 1; HHNMC; HNBC1; KNBC; na(+)/HCO3(-) cotransporter; Na+HCO3- cotransporter 4; NBC-like protein; NBC1; NBC2; Nbc4; PNBC; SLC4A5; sodium bicarbonate cotransporter; solute carrier family 4 (anion exchanger), member 4; solute carrier family 4 sodium bicarbonate cotransporter member 4; solute carrier family 4, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4
Homo sapiens (human) : SLC4A4 (solute carrier family 4 member 4)  HGNC  Alliance
Mus musculus (house mouse) : Slc4a4 (solute carrier family 4 (anion exchanger), member 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc4a4 (solute carrier family 4 member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC4A4 (solute carrier family 4 member 4)
Canis lupus familiaris (dog) : SLC4A4 (solute carrier family 4 member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc4a4 (solute carrier family 4 member 4)
Sus scrofa (pig) : SLC4A4 (solute carrier family 4 member 4)
Chlorocebus sabaeus (African green monkey) : SLC4A4 (solute carrier family 4 member 4)
Heterocephalus glaber (naked mole-rat) : Slc4a4 (solute carrier family 4 member 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01420,476,258 - 20,817,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1420,479,323 - 20,920,286 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01420,382,241 - 20,803,426 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41420,381,545 - 20,739,216 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11420,381,544 - 20,739,216 (-)NCBI
Celera1418,198,665 - 18,528,992 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc4a4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68936
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.