Gene: Penk (proenkephalin) Rattus norvegicus
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Symbol: Penk
Name: proenkephalin
Description: Predicted to have opioid receptor binding activity; involved in several processes, including aging, cellular response to organic cyclic compound, and cellular response to oxidative stress; localizes to several cellular components, including the cytoplasm, neuron projection, and perikaryon; used to study heroin dependence; biomarker of Parkinson's disease, alcohol use disorder, dystonia, and spinal disease; orthologous to human PENK (proenkephalin); INTERACTS WITH (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Enk; enkephalin; MGC93514; Penk-rs; Penk1; Penk2; preproenkephalin 2; preproenkephalin, related sequence; proenkephalin 1; proenkephalin 2; proenkephalin related sequence; proenkephalin, related sequence; proenkephalin-A
Orthologs:
Homo sapiens (human) : PENK (proenkephalin)  HGNC  Alliance
Mus musculus (house mouse) : Penk (preproenkephalin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Penk (proenkephalin)
Pan paniscus (bonobo/pygmy chimpanzee) : PENK (proenkephalin)
Canis lupus familiaris (dog) : PENK (proenkephalin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Penk (proenkephalin)
Sus scrofa (pig) : PENK (proenkephalin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0517,056,412 - 17,061,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0521,834,409 - 21,839,759 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4517,509,323 - 17,514,265 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1517,516,079 - 17,517,452 (-)NCBI
Celera516,529,164 - 16,534,106 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Penk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68946
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.