Gene: Wfs1 (wolframin ER transmembrane glycoprotein) Rattus norvegicus
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Symbol: Wfs1
Name: wolframin ER transmembrane glycoprotein
Description: Exhibits several functions, including activating transcription factor binding activity, calcium-dependent protein binding activity, and calmodulin binding activity; involved in several processes, including negative regulation of ATF6-mediated unfolded protein response, olfactory behavior, and regulation of cellular biosynthetic process; localizes to the integral component of synaptic vesicle membrane; colocalizes with the proteasome complex; biomarker of post-traumatic stress disorder and visual epilepsy; orthologous to human WFS1 (wolframin ER transmembrane glycoprotein); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Wolfram syndrome 1; Wolfram syndrome 1 (wolframin); Wolfram syndrome 1 homolog; Wolfram syndrome 1 homolog (human); wolframin
Orthologs:
Homo sapiens (human) : WFS1 (wolframin ER transmembrane glycoprotein)  HGNC  Alliance
Mus musculus (house mouse) : Wfs1 (wolframin ER transmembrane glycoprotein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wfs1 (wolframin ER transmembrane glycoprotein)
Pan paniscus (bonobo/pygmy chimpanzee) : WFS1 (wolframin ER transmembrane glycoprotein)
Canis lupus familiaris (dog) : WFS1 (wolframin ER transmembrane glycoprotein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wfs1 (wolframin ER transmembrane glycoprotein)
Sus scrofa (pig) : WFS1 (wolframin ER transmembrane glycoprotein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01478,640,707 - 78,665,224 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01478,606,172 - 78,630,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41479,379,680 - 79,404,003 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11479,389,637 - 79,406,394 (+)NCBI
Celera1472,756,725 - 72,781,236 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Wfs1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68954
Created: 2001-11-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.