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Gene: SLC4A4 (solute carrier family 4 member 4) Homo sapiens
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Symbol: SLC4A4
Name: solute carrier family 4 member 4
Description: This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781H1314; electrogenic sodium bicarbonate cotransporter 1; hhNMC; HNBC1; KNBC; kNBC1; Na(+)/HCO3(-) cotransporter; NBC1; NBC2; NBCe1-A; pNBC; SLC4A5; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney, sodium bicarbonate cotransporter, pancreas); solute carrier family 4 (sodium bicarbonate cotransporter), member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5
Orthologs:
Mus musculus (house mouse) : Slc4a4 (solute carrier family 4 (anion exchanger), member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc4a4 (solute carrier family 4 member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc4a4 (solute carrier family 4 member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC4A4 (solute carrier family 4 member 4)
Canis lupus familiaris (dog) : SLC4A4 (solute carrier family 4 member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc4a4 (solute carrier family 4 member 4)
Sus scrofa (pig) : SLC4A4 (solute carrier family 4 member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38471,062,646 - 71,572,087 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37472,053,003 - 72,437,804 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36472,271,867 - 72,656,663 (+)NCBINCBI36hg18NCBI36
Build 34472,569,851 - 72,802,834NCBI
Celera469,409,858 - 69,794,385 (+)NCBI
Cytogenetic Map4q13.3NCBI
HuRef467,858,038 - 68,243,033 (+)NCBIHuRef
CHM1_1472,088,838 - 72,473,646 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC4A4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68964
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.