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Gene: SLC4A4 (solute carrier family 4 member 4) Homo sapiens
Symbol: SLC4A4
Name: solute carrier family 4 member 4
CRRD ID: 68964
Description: Exhibits identical protein binding activity and sodium:bicarbonate symporter activity. Involved in several processes, including bicarbonate transport; positive regulation of glycolytic process; and sodium ion export across plasma membrane. Localizes to basolateral plasma membrane and cell surface. Implicated in renal tubular acidosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781H1314; electrogenic sodium bicarbonate cotransporter 1; hhNMC; HNBC1; KNBC; kNBC1; Na(+)/HCO3(-) cotransporter; NBC1; NBC2; NBCe1-A; pNBC; SLC4A5; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney, sodium bicarbonate cotransporter, pancreas); solute carrier family 4 (sodium bicarbonate cotransporter), member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5
Mus musculus (house mouse) : Slc4a4 (solute carrier family 4 (anion exchanger), member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc4a4 (solute carrier family 4 member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc4a4 (solute carrier family 4 member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC4A4 (solute carrier family 4 member 4)
Canis lupus familiaris (dog) : SLC4A4 (solute carrier family 4 member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc4a4 (solute carrier family 4 member 4)
Sus scrofa (pig) : SLC4A4 (solute carrier family 4 member 4)
Chlorocebus sabaeus (African green monkey) : SLC4A4 (solute carrier family 4 member 4)
Heterocephalus glaber (naked mole-rat) : Slc4a4 (solute carrier family 4 member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl471,062,667 - 71,572,087 (+)EnsemblGRCh38hg38GRCh38
GRCh38471,062,646 - 71,572,083 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37472,053,003 - 72,437,804 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36472,271,867 - 72,656,663 (+)NCBINCBI36hg18NCBI36
Build 34472,569,851 - 72,802,834NCBI
Celera469,409,858 - 69,794,385 (+)NCBI
Cytogenetic Map4q13.3NCBI
HuRef467,858,038 - 68,243,033 (+)NCBIHuRef
CHM1_1472,088,838 - 72,473,646 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC4A4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68964
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.