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Gene: IGF1R (insulin like growth factor 1 receptor) Homo sapiens
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Symbol: IGF1R
Name: insulin like growth factor 1 receptor
Description: Exhibits several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; peptidyl-tyrosine autophosphorylation; and regulation of MAPK cascade. Localizes to the alphav-beta3 integrin-IGF-1-IGF1R complex; intracellular membrane-bounded organelle; and receptor complex. Implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and toxic encephalopathy. Biomarker of several diseases, including Graves' disease; Kuhnt-Junius degeneration; endocrine gland cancer (multiple); neurodegenerative disease (multiple); and prostate disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD221; IGF-I receptor; IGFIR; IGFR; insulin-like growth factor 1 receptor; insulin-like growth factor I receptor; JTK13; MGC142170; MGC142172; MGC18216; soluble IGF1R variant 1; soluble IGF1R variant 2
Orthologs:
Mus musculus (house mouse) : Igf1r (insulin-like growth factor I receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Igf1r (insulin-like growth factor 1 receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igf1r (insulin like growth factor 1 receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : IGF1R (insulin like growth factor 1 receptor)
Canis lupus familiaris (dog) : IGF1R (insulin like growth factor 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igf1r (insulin like growth factor 1 receptor)
Sus scrofa (pig) : IGF1R (insulin like growth factor 1 receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381598,648,539 - 98,964,530 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371599,192,272 - 99,507,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,010,284 - 97,325,282 (+)NCBINCBI36hg18NCBI36
Build 341597,010,287 - 97,319,034NCBI
Celera1575,609,678 - 75,924,704 (+)NCBI
Cytogenetic Map15q26.3NCBI
HuRef1575,320,348 - 75,635,223 (+)NCBIHuRef
CHM1_11599,033,296 - 99,349,171 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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