Gene: PENK (proenkephalin) Homo sapiens
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Symbol: PENK
Name: proenkephalin
Description: This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: enkephalin A; PE; PENK-A; peptide F; preproenkephalin; proenkephalin-A
Orthologs:
Mus musculus (house mouse) : Penk (preproenkephalin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Penk (proenkephalin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Penk (proenkephalin)
Pan paniscus (bonobo/pygmy chimpanzee) : PENK (proenkephalin)
Canis lupus familiaris (dog) : PENK (proenkephalin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Penk (proenkephalin)
Sus scrofa (pig) : PENK (proenkephalin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38856,440,954 - 56,446,734 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37857,353,513 - 57,359,282 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36857,516,070 - 57,521,143 (-)NCBINCBI36hg18NCBI36
Build 34857,516,069 - 57,521,143NCBI
Celera853,344,310 - 53,350,077 (-)NCBI
Cytogenetic Map8q12.1NCBI
HuRef852,820,608 - 52,826,373 (-)NCBIHuRef
CHM1_1857,405,395 - 57,411,169 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PENK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 68998
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.