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Gene: ITGA1 (integrin subunit alpha 1) Homo sapiens
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Symbol: ITGA1
Name: integrin subunit alpha 1
Description: Exhibits collagen binding activity involved in cell-matrix adhesion and protein phosphatase binding activity. Involved in cell-matrix adhesion; negative regulation of cell population proliferation; and positive regulation of phosphoprotein phosphatase activity. Localizes to the cell surface; focal adhesion; and integrin alpha1-beta1 complex. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD49 antigen-like family member A; CD49a; integrin alpha 1; integrin alpha-1; integrin, alpha 1; laminin and collagen receptor; very late activation protein 1; VLA-1; VLA1
Orthologs:
Mus musculus (house mouse) : Itga1 (integrin alpha 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itga1 (integrin subunit alpha 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itga1 (integrin subunit alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGA1 (integrin subunit alpha 1)
Canis lupus familiaris (dog) : ITGA1 (integrin subunit alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itga1 (integrin subunit alpha 1)
Sus scrofa (pig) : ITGA1 (integrin subunit alpha 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38552,787,916 - 52,959,209 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37552,084,136 - 52,249,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,119,893 - 52,285,242 (+)NCBINCBI36hg18NCBI36
Build 34552,119,892 - 52,285,241NCBI
Celera549,037,686 - 49,203,085 (+)NCBI
Cytogenetic Map5q11.2NCBI
HuRef549,055,982 - 49,221,542 (+)NCBIHuRef
CHM1_1552,086,786 - 52,252,111 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ITGA1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69006
Created: 2001-11-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.