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Gene: INSR (insulin receptor) Homo sapiens
Symbol: INSR
Name: insulin receptor
CRRD ID: 69029
Description: Exhibits several functions, including insulin-like growth factor binding activity; peptide binding activity; and purine ribonucleoside triphosphate binding activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of glucose import; and protein phosphorylation. Localizes to caveola and insulin receptor complex. Colocalizes with nuclear envelope and nuclear lumen. Implicated in Donohue syndrome; diabetes mellitus (multiple); familial hyperinsulinemic hypoglycemia 5; and reproductive organ cancer (multiple). Biomarker of Alzheimer's disease; breast cancer; hepatocellular carcinoma; renal cell carcinoma; and seminoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD220; HHF5; IR
Mus musculus (house mouse) : Insr (insulin receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Insr (insulin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Insr (insulin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : INSR (insulin receptor)
Canis lupus familiaris (dog) : INSR (insulin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Insr (insulin receptor)
Sus scrofa (pig) : INSR (insulin receptor)
Chlorocebus sabaeus (African green monkey) : INSR (insulin receptor)
Heterocephalus glaber (naked mole-rat) : Insr (insulin receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl197,112,255 - 7,294,414 (-)EnsemblGRCh38hg38GRCh38
GRCh38197,112,257 - 7,294,414 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,112,266 - 7,294,011 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,063,266 - 7,245,011 (-)NCBINCBI36hg18NCBI36
Build 34197,067,637 - 7,245,011NCBI
Celera197,049,684 - 7,205,258 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef196,846,024 - 7,028,322 (-)NCBIHuRef
CHM1_1197,111,894 - 7,294,726 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences