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Gene: Nr1i2 (nuclear receptor subfamily 1, group I, member 2) Rattus norvegicus
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Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Description: Exhibits nuclear receptor activity. Predicted to be involved in several processes, including cholesterol homeostasis; exogenous drug catabolic process; and regulation of transcription by RNA polymerase II. Localizes to nucleus. Biomarker of cholestasis and epilepsy. Orthologous to human NR1I2 (nuclear receptor subfamily 1 group I member 2); INTERACTS WITH (+)-schisandrin B; (+)-trans-(S)-allethrin; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC108643; nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; orphan nuclear receptor PXR; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); PXR
Orthologs:
Homo sapiens (human) : NR1I2 (nuclear receptor subfamily 1 group I member 2)  HGNC  Alliance
Mus musculus (house mouse) : Nr1i2 (nuclear receptor subfamily 1, group I, member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1i2 (nuclear receptor subfamily 1 group I member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1I2 (nuclear receptor subfamily 1 group I member 2)
Canis lupus familiaris (dog) : NR1I2 (nuclear receptor subfamily 1 group I member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1i2 (nuclear receptor subfamily 1 group I member 2)
Sus scrofa (pig) : NR1I2 (nuclear receptor subfamily 1 group I member 2)
Chlorocebus sabaeus (African green monkey) : NR1I2 (nuclear receptor subfamily 1 group I member 2)
Heterocephalus glaber (naked mole-rat) : Nr1i2 (nuclear receptor subfamily 1 group I member 2)
more info ...
Allele / Splice: Nr1i2em1Sage  
Genetic Models: SD-Nr1i2em1Sage SD-Nr1i2em1Sage Nr1i3em1Sage SD-Nr1i2em1Sage Nr1i3em1Sage Ahrem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01165,022,100 - 65,058,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,022,100 - 65,058,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01167,024,185 - 67,060,494 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,239,918 - 64,276,702 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11164,297,534 - 64,333,716 (+)NCBI
Celera1161,960,674 - 61,997,009 (+)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nr1i2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69057
Created: 2001-11-08
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.