Gene: Pawr (pro-apoptotic WT1 regulator) Rattus norvegicus
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Symbol: Pawr
Name: pro-apoptotic WT1 regulator
Description: Exhibits actin binding activity, protein kinase C binding activity, and protein phosphatase 1 binding activity; involved in several processes, including cellular response to hormone stimulus, detection of stimulus involved in sensory perception, and positive regulation of cellular metabolic process; localizes to the axon, cytoplasm, and neuronal cell body; colocalizes with the actin filament; biomarker of mental depression, middle cerebral artery infarction, transient cerebral ischemia, and visual epilepsy; orthologous to human PAWR (pro-apoptotic WT1 regulator); PARTICIPATES IN ceramide signaling pathway; INTERACTS WITH (+)-alpha-tocopherol; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; (S)-colchicine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Par-4; par-4 induced by effectors of apoptosis; Par4; PRKC apoptosis WT1 regulator; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; transcriptional repressor Par-4-like protein PAWR
Orthologs:
Homo sapiens (human) : PAWR (pro-apoptotic WT1 regulator)  HGNC  Alliance
Mus musculus (house mouse) : Pawr (PRKC, apoptosis, WT1, regulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pawr (pro-apoptotic WT1 regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : PAWR (pro-apoptotic WT1 regulator)
Canis lupus familiaris (dog) : PAWR (pro-apoptotic WT1 regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pawr (pro-apoptotic WT1 regulator)
Sus scrofa (pig) : PAWR (pro-apoptotic WT1 regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0751,273,764 - 51,353,700 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0751,286,663 - 51,366,383 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4747,040,162 - 47,119,613 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1747,060,432 - 47,139,881 (+)NCBI
Celera740,512,247 - 40,591,588 (+)NCBICelera
Cytogenetic Map7q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pawr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69065
Created: 2001-11-08
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.