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Gene: HNF4A (hepatocyte nuclear factor 4 alpha) Homo sapiens
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Symbol: HNF4A
Name: hepatocyte nuclear factor 4 alpha
Description: Exhibits several functions, including DNA-binding transcription factor activity; fatty acid binding activity; and protein homodimerization activity. Involved in several processes, including blood coagulation; ornithine metabolic process; and regulation of transcription, DNA-templated. Localizes to the cytoplasm and nucleoplasm. Implicated in Fanconi syndrome; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Biomarker of hepatocellular carcinoma and liver cirrhosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ39654; FRTS4; hepatic nuclear factor 4 alpha; hepatocyte nuclear factor 4 4 alpha variant 1; hepatocyte nuclear factor 4 4 alpha variant 2; hepatocyte nuclear factor 4 4 alpha variant 4; hepatocyte nuclear factor 4, alpha; hepatocyte nuclear factor 4-alpha; HNF-4-alpha; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4alpha10/11/12; MODY; MODY1; NR2A1; NR2A21; nuclear receptor subfamily 2 group A member 1; TCF; TCF-14; TCF14; transcription factor 14; transcription factor HNF-4; transcription factor-14
Orthologs:
Mus musculus (house mouse) : Hnf4a (hepatic nuclear factor 4, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hnf4a (hepatocyte nuclear factor 4, alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF4A (hepatocyte nuclear factor 4 alpha)
Canis lupus familiaris (dog) : HNF4A (hepatocyte nuclear factor 4 alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf4a (hepatocyte nuclear factor 4 alpha)
Sus scrofa (pig) : HNF4A (hepatocyte nuclear factor 4 alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382044,355,699 - 44,434,596 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372042,984,441 - 43,061,485 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,417,855 - 42,493,444 (+)NCBINCBI36hg18NCBI36
Build 342042,463,337 - 42,486,690NCBI
Celera2039,693,092 - 39,768,681 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2039,720,990 - 39,802,805 (+)NCBIHuRef
CHM1_12042,886,684 - 42,964,390 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on HNF4A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69093
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.