Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Jak1 (Janus kinase 1) Mus musculus
Symbol: Jak1
Name: Janus kinase 1
Description: Exhibits growth hormone receptor binding activity and protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; cellular response to cytokine stimulus; and positive regulation of receptor signaling pathway via STAT. Predicted to localize to the cytoplasm and nucleus. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human JAK1 (Janus kinase 1); PARTICIPATES IN Interleukin-10 signaling pathway; interleukin-2 signaling pathway; interleukin-27 signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA960307; BAP004; C130039L05Rik; JAK-1; MGC37919; tyrosine-protein kinase JAK1
Homo sapiens (human) : JAK1 (Janus kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Jak1 (Janus kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Jak1 (Janus kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : JAK1 (Janus kinase 1)
Canis lupus familiaris (dog) : JAK1 (Janus kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Jak1 (Janus kinase 1)
Sus scrofa (pig) : JAK1 (Janus kinase 1)
Chlorocebus sabaeus (African green monkey) : JAK1 (Janus kinase 1)
Heterocephalus glaber (naked mole-rat) : Jak1 (Janus kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl4101,152,367 - 101,265,282 (-)EnsemblGRCm38mm10GRCm38
GRCm384101,151,974 - 101,265,282 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374100,824,579 - 100,937,887 (-)NCBIGRCm37mm9NCBIm37
MGSCv364100,650,964 - 100,763,165 (-)NCBImm8
Celera499,494,673 - 99,536,518 (-)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Cell Lines
Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Jak1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69103
Created: 2001-11-08
Species: Mus musculus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.