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Gene: PDK4 (pyruvate dehydrogenase kinase 4) Homo sapiens
Symbol: PDK4
Name: pyruvate dehydrogenase kinase 4
Description: Exhibits ATP binding activity and protein kinase activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of anoikis; and regulation of fatty acid metabolic process. Predicted to localize to mitochondrion.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial; FLJ40832; pyruvate dehydrogenase kinase, isoenzyme 4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial
Mus musculus (house mouse) : Pdk4 (pyruvate dehydrogenase kinase, isoenzyme 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdk4 (pyruvate dehydrogenase kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdk4 (pyruvate dehydrogenase kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : PDK4 (pyruvate dehydrogenase kinase 4)
Canis lupus familiaris (dog) : PDK4 (pyruvate dehydrogenase kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdk4 (pyruvate dehydrogenase kinase 4)
Sus scrofa (pig) : PDK4 (pyruvate dehydrogenase kinase 4)
Chlorocebus sabaeus (African green monkey) : PDK4 (pyruvate dehydrogenase kinase 4)
Heterocephalus glaber (naked mole-rat) : Pdk4 (pyruvate dehydrogenase kinase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl795,583,499 - 95,596,516 (-)EnsemblGRCh38hg38GRCh38
GRCh38795,583,499 - 95,596,516 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37795,212,809 - 95,225,925 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36795,050,745 - 95,063,861 (-)NCBINCBI36hg18NCBI36
Build 34794,857,461 - 94,870,454NCBI
Celera789,911,513 - 89,924,633 (-)NCBI
Cytogenetic Map7q21.3NCBI
HuRef789,819,915 - 89,833,034 (-)NCBIHuRef
CHM1_1795,142,829 - 95,155,944 (-)NCBICHM1_1
CRA_TCAGchr7v2794,541,818 - 94,554,938 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PDK4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69113
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2020-05-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.