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Gene: Cdkn1b (cyclin-dependent kinase inhibitor 1B) Mus musculus
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Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Description: Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including animal organ development; negative regulation of cell cycle; and regulation of organelle organization. Localizes to the cytosol and nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Is expressed in several structures, including central nervous system; genitourinary system; heart and pericardium; hemolymphoid system; and sensory organ. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B); PARTICIPATES IN forkhead class A signaling pathway; G1/S transition pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408329; AI843786; cyclin-dependent kinase inhibitor p27; Kip1; p27; p27Kip1
Orthologs:
Homo sapiens (human) : CDKN1B (cyclin dependent kinase inhibitor 1B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cdkn1b (cyclin-dependent kinase inhibitor 1B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Canis lupus familiaris (dog) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
Sus scrofa (pig) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Chlorocebus sabaeus (African green monkey) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Heterocephalus glaber (naked mole-rat) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl6134,920,401 - 134,925,513 (+)Ensembl
GRCm386134,920,401 - 134,925,525 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376134,870,419 - 134,875,543 (+)NCBIGRCm37mm9NCBIm37
MGSCv366134,886,110 - 134,889,751 (+)NCBImm8
Celera6137,877,174 - 137,882,301 (+)NCBICelera
Cytogenetic Map6 G1NCBI
cM Map665.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cdkn1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69116
Created: 2001-11-08
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.