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Gene: PAWR (pro-apoptotic WT1 regulator) Homo sapiens
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Symbol: PAWR
Name: pro-apoptotic WT1 regulator
Description: Exhibits enzyme binding activity and leucine zipper domain binding activity. Predicted to be involved in actin filament bundle assembly; apoptotic process; and positive regulation of apoptotic process. Localizes to several cellular components, including the actin cytoskeleton; nucleus; and plasma membrane. Biomarker of Alzheimer's disease; cholangiocarcinoma; and major depressive disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Par-4; PAR4; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; transcriptional repressor PAR4; WT1-interacting protein
Orthologs:
Mus musculus (house mouse) : Pawr (PRKC, apoptosis, WT1, regulator)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pawr (pro-apoptotic WT1 regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pawr (pro-apoptotic WT1 regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : PAWR (pro-apoptotic WT1 regulator)
Canis lupus familiaris (dog) : PAWR (pro-apoptotic WT1 regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pawr (pro-apoptotic WT1 regulator)
Sus scrofa (pig) : PAWR (pro-apoptotic WT1 regulator)
more info ...
Related Pseudogenes: PAWRP1   PAWRP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381279,584,874 - 79,691,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371279,985,745 - 80,084,877 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361278,509,876 - 78,608,921 (-)NCBINCBI36hg18NCBI36
Build 341278,488,214 - 78,587,258NCBI
Celera1279,652,459 - 79,751,312 (-)NCBI
Cytogenetic Map12q21.2NCBI
HuRef1277,042,009 - 77,141,117 (-)NCBIHuRef
CHM1_11279,952,168 - 80,051,122 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PAWR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69120
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.