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Gene: LEP (leptin) Homo sapiens
Symbol: LEP
Name: leptin
Description: Predicted to have hormone activity and peptide hormone receptor binding activity. Involved in several processes, including cytokine secretion; positive regulation of signal transduction; and regulation of lymphocyte proliferation. Predicted to localize to the extracellular space. Implicated in congenital leptin deficiency; hypertension; lung disease (multiple); osteoporosis; and rhinitis. Biomarker of several diseases, including bone disease (multiple); cystic fibrosis; end stage renal failure; liver disease (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ94114; LEPD; leptin (murine obesity homolog); leptin (obesity homolog, mouse); OB; obese protein; obese, mouse, homolog of; obesity factor; OBS
Mus musculus (house mouse) : Lep (leptin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lep (leptin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lep (leptin)
Pan paniscus (bonobo/pygmy chimpanzee) : LEP (leptin)
Canis lupus familiaris (dog) : LEP (leptin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lep (leptin)
Sus scrofa (pig) : LEP (leptin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387128,241,201 - 128,257,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377127,881,241 - 127,897,682 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367127,668,567 - 127,684,917 (+)NCBINCBI36hg18NCBI36
Build 347127,475,281 - 127,491,632NCBI
Celera7122,684,619 - 122,700,967 (+)NCBI
Cytogenetic Map7q32.1NCBI
HuRef7122,242,298 - 122,258,647 (+)NCBIHuRef
CHM1_17127,814,632 - 127,830,980 (+)NCBICHM1_1
CRA_TCAGchr7v27127,264,455 - 127,280,803 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on LEP
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69123
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.