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Gene: Lep (leptin) Mus musculus
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Symbol: Lep
Name: leptin
Description: Exhibits DNA binding activity and growth factor activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of signal transduction; and regulation of peptide transport. Localizes to cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and obesity. Orthologous to human LEP (leptin); PARTICIPATES IN hypoxia inducible factor pathway; energy homeostasis pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-catechin; (+)-epicatechin-3-O-gallate; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ob; obese; obesity factor
Orthologs:
Homo sapiens (human) : LEP (leptin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lep (leptin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lep (leptin)
Pan paniscus (bonobo/pygmy chimpanzee) : LEP (leptin)
Canis lupus familiaris (dog) : LEP (leptin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lep (leptin)
Sus scrofa (pig) : LEP (leptin)
Chlorocebus sabaeus (African green monkey) : LEP (leptin)
Heterocephalus glaber (naked mole-rat) : Lep (leptin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl629,060,220 - 29,073,877 (+)EnsemblGRCm38mm10GRCm38
GRCm38629,060,221 - 29,073,876 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37629,010,221 - 29,023,876 (+)NCBIGRCm37mm9NCBIm37
MGSCv36629,010,231 - 29,023,886 (+)NCBImm8
Celera629,063,769 - 29,077,429 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated