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Gene: GCKR (glucokinase regulator) Homo sapiens
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Symbol: GCKR
Name: glucokinase regulator
Description: Exhibits fructose-6-phosphate binding activity. Involved in several processes, including negative regulation of glucokinase activity; response to fructose; and triglyceride homeostasis. Predicted to localize to the cytosol; mitochondrion; and nucleoplasm. Implicated in end stage renal failure and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FGQTL5; GKRP; glucokinase (hexokinase 4) regulator; glucokinase (hexokinase 4) regulatory protein; glucokinase regulatory protein; hexokinase 4; hexokinase 4 regulator
Orthologs:
Mus musculus (house mouse) : Gckr (glucokinase regulatory protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gckr (glucokinase regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gckr (glucokinase regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : GCKR (glucokinase regulator)
Canis lupus familiaris (dog) : GCKR (glucokinase regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gckr (glucokinase regulator)
Sus scrofa (pig) : GCKR (glucokinase regulator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,496,839 - 27,523,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37227,719,470 - 27,746,556 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,573,210 - 27,600,055 (+)NCBINCBI36hg18NCBI36
Build 34227,631,356 - 27,658,199NCBI
Celera227,565,881 - 27,592,728 (+)NCBI
Cytogenetic Map2p23.3NCBI
HuRef227,461,595 - 27,488,434 (+)NCBIHuRef
CHM1_1227,649,617 - 27,676,462 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GCKR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69130
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.