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Gene: Rasgrp1 (RAS guanyl releasing protein 1) Mus musculus
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Symbol: Rasgrp1
Name: RAS guanyl releasing protein 1
Description: Predicted to have several functions, including cation binding activity; diacylglycerol binding activity; and protein homodimerization activity. Involved in several processes, including activation of GTPase activity; mast cell degranulation; and positive regulation of lymphocyte differentiation. Predicted to localize to the Golgi apparatus; cytosol; and plasma membrane. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in brain; olfactory epithelium; olfactory lobe; and telencephalon mantle layer. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,1-dichloroethene; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calcium and DAG-regulated guanine nucleotide exchange factor II; calDAG-GEFII; RAS guanyl-releasing protein 1; Rasgrp
Orthologs:
Homo sapiens (human) : RASGRP1 (RAS guanyl releasing protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Rasgrp1 (RAS guanyl releasing protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rasgrp1 (RAS guanyl releasing protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RASGRP1 (RAS guanyl releasing protein 1)
Canis lupus familiaris (dog) : RASGRP1 (RAS guanyl releasing protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rasgrp1 (RAS guanyl releasing protein 1)
Sus scrofa (pig) : RASGRP1 (RAS guanyl releasing protein 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382117,279,983 - 117,342,877 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372117,105,729 - 117,168,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv362116,971,434 - 117,034,318 (-)NCBImm8
Celera2118,408,657 - 118,471,539 (-)NCBICelera
Cytogenetic Map2 E5NCBI
cM Map259.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Rasgrp1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69138
Created: 2001-11-08
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.