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Gene: NPPB (natriuretic peptide B) Homo sapiens
Symbol: NPPB
Name: natriuretic peptide B
Description: Exhibits hormone receptor binding activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cGMP biosynthetic process; and receptor guanylyl cyclase signaling pathway. Localizes to the protein-containing complex. Implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Biomarker of several diseases, including Kawasaki disease; artery disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and kidney failure (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BNP; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B; natriuretic peptides B; natriuretic protein
Mus musculus (house mouse) : Nppb (natriuretic peptide type B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nppb (natriuretic peptide B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nppb (natriuretic peptide B)
Pan paniscus (bonobo/pygmy chimpanzee) : NPPB (natriuretic peptide B)
Canis lupus familiaris (dog) : NPPB (natriuretic peptide B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nppb (natriuretic peptide B)
Sus scrofa (pig) : NPPB (natriuretic peptide B)
Chlorocebus sabaeus (African green monkey) : NPPB (natriuretic peptide B)
Heterocephalus glaber (naked mole-rat) : Nppb (natriuretic peptide B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl111,857,464 - 11,858,945 (-)Ensembl
GRCh38111,857,464 - 11,858,945 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37111,917,521 - 11,918,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,840,108 - 11,841,579 (-)NCBINCBI36hg18NCBI36
Build 34111,851,789 - 11,853,254NCBI
Celera111,031,156 - 11,032,627 (-)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,073,021 - 11,074,492 (-)NCBIHuRef
CHM1_1111,905,417 - 11,906,888 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NPPB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69139
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.