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Gene: GHR (growth hormone receptor) Homo sapiens
Symbol: GHR
Name: growth hormone receptor
Description: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GH receptor; GHBP; GHIP; growth hormone binding protein; serum binding protein; somatotropin receptor
Mus musculus (house mouse) : Ghr (growth hormone receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ghr (growth hormone receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ghr (growth hormone receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : GHR (growth hormone receptor)
Canis lupus familiaris (dog) : GHR (growth hormone receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ghr (growth hormone receptor)
Sus scrofa (pig) : GHR (growth hormone receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38542,423,775 - 42,721,878 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37542,423,577 - 42,721,980 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36542,459,783 - 42,757,683 (+)NCBINCBI36hg18NCBI36
Build 34542,459,782 - 42,757,682NCBI
Celera542,314,115 - 42,611,474 (+)NCBI
Cytogenetic Map5p13.1-p12NCBI
HuRef542,375,464 - 42,673,429 (+)NCBIHuRef
CHM1_1542,425,901 - 42,723,964 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on GHR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69149
Created: 2001-11-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.