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Gene: EGFR (epidermal growth factor receptor) Homo sapiens
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Symbol: EGFR
Name: epidermal growth factor receptor
Description: Exhibits several functions, including enzyme binding activity; epidermal growth factor-activated receptor activity; and protein heterodimerization activity. Contributes to nitric-oxide synthase regulator activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of intracellular signal transduction; and regulation of protein phosphorylation. Localizes to several cellular components, including the basolateral plasma membrane; endosome; and membrane raft. Implicated in several diseases, including breast carcinoma; colorectal cancer; lung cancer (multiple); pancreatic cancer; and prostate cancer. Biomarker of several diseases, including breast cancer (multiple); carcinoma (multiple); diabetic retinopathy; liver cirrhosis; and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian); epidermal growth factor receptor tyrosine kinase domain; erb-b2 receptor tyrosine kinase 1; ERBB; ERBB1; erythroblastic leukemia viral (v-erb-b) oncogene homolog; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1
Orthologs:
Mus musculus (house mouse) : Egfr (epidermal growth factor receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Egfr (epidermal growth factor receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egfr (epidermal growth factor receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : EGFR (epidermal growth factor receptor)
Canis lupus familiaris (dog) : EGFR (epidermal growth factor receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egfr (epidermal growth factor receptor)
Sus scrofa (pig) : EGFR (epidermal growth factor receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38755,019,017 - 55,211,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37755,086,678 - 55,279,262 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36755,054,219 - 55,242,525 (+)NCBINCBI36hg18NCBI36
Build 34754,860,933 - 55,012,947NCBI
Celera755,192,332 - 55,380,657 (+)NCBI
Cytogenetic Map7p11.2NCBI
HuRef754,924,934 - 55,112,834 (+)NCBIHuRef
CHM1_1755,089,165 - 55,277,398 (+)NCBICHM1_1
CRA_TCAGchr7v2755,092,507 - 55,280,831 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated