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Gene: Nfix (nuclear factor I/X) Mus musculus
Symbol: Nfix
Name: nuclear factor I/X
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in central nervous system development and regulation of transcription by RNA polymerase II. Predicted to localize to the nucleus. Used to study Scheuermann's disease. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human NFIX (nuclear factor I X); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CCAAT-box-binding transcription factor; CTF; NF-I/X; NF1-X; NFI-X; nuclear factor 1 X-type; nuclear factor 1/X; TGGCA-binding protein
Homo sapiens (human) : NFIX (nuclear factor I X)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nfix (nuclear factor I X)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfix (nuclear factor I X)
Pan paniscus (bonobo/pygmy chimpanzee) : NFIX (nuclear factor I X)
Canis lupus familiaris (dog) : NFIX (nuclear factor I X)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfix (nuclear factor I X)
Sus scrofa (pig) : NFIX (nuclear factor I X)
Chlorocebus sabaeus (African green monkey) : NFIX (nuclear factor I X)
Heterocephalus glaber (naked mole-rat) : Nfix (nuclear factor I X)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl884,699,876 - 84,800,344 (-)EnsemblGRCm38mm10GRCm38
GRCm38884,704,712 - 84,801,238 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37887,231,498 - 87,324,239 (-)NCBIGRCm37mm9NCBIm37
MGSCv36887,598,719 - 87,690,245 (-)NCBImm8
Celera889,007,669 - 89,082,215 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map841.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nfix
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69162
Created: 2001-11-08
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.