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Gene: Ucp2 (uncoupling protein 2 (mitochondrial, proton carrier)) Mus musculus
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Symbol: Ucp2
Name: uncoupling protein 2 (mitochondrial, proton carrier)
Description: Predicted to have oxidative phosphorylation uncoupler activity. Involved in positive regulation of cold-induced thermogenesis and regulation of mitochondrial membrane potential. Localizes to the mitochondrion. Used to study polycystic liver disease. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal failure; non-alcoholic fatty liver disease; and obesity. Is expressed in several structures, including adipose tissue; hemolymphoid system; integumental system; nose; and skeletal muscle. Orthologous to human UCP2 (uncoupling protein 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mitochondrial uncoupling protein 2; Slc25a8; solute carrier family 25 member 8; UCP 2; UCPH; uncoupling protein 2, mitochondrial
Orthologs:
Homo sapiens (human) : UCP2 (uncoupling protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ucp2 (uncoupling protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ucp2 (uncoupling protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : UCP2 (uncoupling protein 2)
Canis lupus familiaris (dog) : UCP2 (uncoupling protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ucp2 (uncoupling protein 2)
Sus scrofa (pig) : UCP2 (uncoupling protein 2)
Chlorocebus sabaeus (green monkey) : UCP2 (uncoupling protein 2)
Heterocephalus glaber (naked mole-rat) : Ucp2 (uncoupling protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl7100,493,337 - 100,502,020 (+)Ensembl
GRCm387100,493,337 - 100,499,629 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377107,641,854 - 107,650,682 (+)NCBIGRCm37mm9NCBIm37
MGSCv367100,367,446 - 100,376,102 (+)NCBImm8
Celera7100,830,949 - 100,837,202 (+)NCBICelera
Cytogenetic Map7 E2NCBI
cM Map754.36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ucp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69171
Created: 2001-11-08
Species: Mus musculus
Last Modified: 2020-01-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.