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Gene: Gphn (gephyrin) Rattus norvegicus
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Symbol: Gphn
Name: gephyrin
Description: Exhibits several functions, including molybdopterin adenylyltransferase activity; molybdopterin molybdotransferase activity; and protein homodimerization activity. Involved in several processes, including Mo-molybdopterin cofactor biosynthetic process; neurotransmitter receptor localization to postsynaptic specialization membrane; and protein homooligomerization. Localizes to several cellular components, including the extrinsic component of cytoplasmic side of plasma membrane; glycinergic synapse; and postsynaptic specialization, intracellular component. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin); PARTICIPATES IN molybdenum cofactor biosynthetic pathway; Inhibitory synaptic transmission pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Geph; gephyrin isoform; putative glycine receptor-tubulin linker protein
Orthologs:
Homo sapiens (human) : GPHN (gephyrin)  HGNC  Alliance
Mus musculus (house mouse) : Gphn (gephyrin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gphn (gephyrin)
Pan paniscus (bonobo/pygmy chimpanzee) : GPHN (gephyrin)
Canis lupus familiaris (dog) : GPHN (gephyrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gphn (gephyrin)
Sus scrofa (pig) : GPHN (gephyrin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06101,327,874 - 101,859,169 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06111,210,069 - 111,237,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.06110,709,516 - 111,190,440 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46100,833,004 - 101,302,957 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16100,836,459 - 101,306,408 (+)NCBI
Celera695,358,601 - 95,872,910 (+)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gphn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69194
Created: 2001-11-13
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.