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Gene: CYP27B1 (cytochrome P450 family 27 subfamily B member 1) Homo sapiens
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Symbol: CYP27B1
Name: cytochrome P450 family 27 subfamily B member 1
Description: Exhibits calcidiol 1-monooxygenase activity. Involved in several processes, including decidualization; negative regulation of calcidiol 1-monooxygenase activity; and positive regulation of vitamin D 24-hydroxylase activity. Localizes to the cytoplasm. Implicated in obesity; rickets; and type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1alpha(OH)ase; 25 hydroxyvitamin D3-1-alpha hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; 25-OHD-1 alpha-hydroxylase; calcidiol 1-monooxygenase; CP2B; CYP1; CYP1alpha; CYP27B; cytochrome p450 27B1; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, family 27, subfamily B, polypeptide 1; cytochrome P450C1 alpha; cytochrome P450VD1-alpha; P450c1; PDDR; VD3 1A hydroxylase; VDD1; VDDR; VDDRI; VDR
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,762,334 - 57,767,078 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371258,156,117 - 58,160,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,442,384 - 56,447,243 (-)NCBINCBI36hg18NCBI36
Build 341256,442,385 - 56,447,151NCBI
Celera1257,813,712 - 57,818,571 (-)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1255,192,956 - 55,197,815 (-)NCBIHuRef
CHM1_11258,123,921 - 58,128,780 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CYP27B1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69201
Created: 2001-11-13
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.