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Gene: Htra1 (HtrA serine peptidase 1) Rattus norvegicus
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Symbol: Htra1
Name: HtrA serine peptidase 1
Description: Predicted to have identical protein binding activity and serine-type peptidase activity. Involved in dentinogenesis; negative regulation of defense response to virus; and positive regulation of epithelial cell proliferation. Localizes to the collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: high-temperature requirement A serine peptidase 1; MGC93339; protease serine 11; protease serine 11 (Igf binding); protease, serine, 11; protease, serine, 11 (Igf binding); Prss11; serine protease 11; serine protease HTRA1
Orthologs:
Homo sapiens (human) : HTRA1 (HtrA serine peptidase 1)  HGNC  Alliance
Mus musculus (house mouse) : Htra1 (HtrA serine peptidase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Htra1 (HtrA serine peptidase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HTRA1 (HtrA serine peptidase 1)
Canis lupus familiaris (dog) : HTRA1 (HtrA serine peptidase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Htra1 (HtrA serine peptidase 1)
Sus scrofa (pig) : HTRA1 (HtrA serine peptidase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01201,499,067 - 201,548,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01208,532,013 - 208,581,538 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41190,257,899 - 190,308,325 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11190,407,779 - 190,458,206 (+)NCBI
Celera1183,110,143 - 183,159,496 (+)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Htra1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69235
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.