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Gene: Tcf4 (transcription factor 4) Rattus norvegicus
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Symbol: Tcf4
Name: transcription factor 4
Description: Exhibits bHLH transcription factor binding activity and double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to the beta-catenin-TCF7L2 complex and nuclear chromatin. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: immunoglobulin transcription factor 2; ITF-2; R8f DNA-binding protein; RITF-2; SEF-2; SL3-3 enhancer factor 2; TCF-4
Orthologs:
Homo sapiens (human) : TCF4 (transcription factor 4)  HGNC  Alliance
Mus musculus (house mouse) : Tcf4 (transcription factor 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tcf4 (transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TCF4 (transcription factor 4)
Canis lupus familiaris (dog) : TCF4 (transcription factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tcf4 (transcription factor 4)
Sus scrofa (pig) : TCF4 (transcription factor 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01865,285,320 - 65,507,983 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01864,471,373 - 64,694,036 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41866,135,863 - 66,359,984 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11866,209,063 - 66,433,179 (+)NCBI
Celera1861,145,273 - 61,368,542 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tcf4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69271
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.