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Gene: Socs1 (suppressor of cytokine signaling 1) Rattus norvegicus
Symbol: Socs1
Name: suppressor of cytokine signaling 1
Description: Predicted to have insulin-like growth factor receptor binding activity; kinase regulator activity; and protein kinase binding activity. Involved in several processes, including response to estradiol; response to lipopolysaccharide; and response to progesterone. Predicted to localize to cytoplasmic ribonucleoprotein granule; nucleoplasm; and phosphatidylinositol 3-kinase complex. Biomarker of myocardial infarction and obesity. Human ortholog(s) of this gene implicated in ovarian carcinoma; prostate cancer; and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1); PARTICIPATES IN insulin signaling pathway; interleukin-12 signaling pathway; interleukin-2 signaling pathway; INTERACTS WITH 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cish1; cytokine inducible SH2-containing protein 1; Socs-1
Homo sapiens (human) : SOCS1 (suppressor of cytokine signaling 1)  HGNC  Alliance
Mus musculus (house mouse) : Socs1 (suppressor of cytokine signaling 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs1 (suppressor of cytokine signaling 1)
Canis lupus familiaris (dog) : SOCS1 (suppressor of cytokine signaling 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs1 (suppressor of cytokine signaling 1)
Sus scrofa (pig) : SOCS1 (suppressor of cytokine signaling 1)
Chlorocebus sabaeus (African green monkey) : SOCS1 (suppressor of cytokine signaling 1)
Heterocephalus glaber (naked mole-rat) : Socs1 (suppressor of cytokine signaling 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0104,956,795 - 4,958,472 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl104,957,326 - 4,958,461 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0103,782,936 - 3,783,574 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4104,819,971 - 4,820,609 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1104,819,970 - 4,820,609 (+)NCBI
Celera103,904,246 - 3,905,811 (+)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Socs1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69272
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.