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Gene: Sh2b2 (SH2B adaptor protein 2) Rattus norvegicus
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Symbol: Sh2b2
Name: SH2B adaptor protein 2
Description: Exhibits identical protein binding activity. Involved in nervous system development and regulation of Ras protein signal transduction. Predicted to localize to several cellular components, including the actin cytoskeleton; cytosol; and ruffle. Orthologous to human SH2B2 (SH2B adaptor protein 2); PARTICIPATES IN insulin signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: adapter protein with pleckstrin homology and Src homology 2 domains; adaptor protein with pleckstrin homology and src homology 2 domains; Aps; SH2 and PH domain-containing adapter protein APS; SH2B adapter protein 2
Orthologs:
Homo sapiens (human) : SH2B2 (SH2B adaptor protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Sh2b2 (SH2B adaptor protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b2 (SH2B adaptor protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B2 (SH2B adaptor protein 2)
Canis lupus familiaris (dog) : SH2B2 (SH2B adaptor protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b2 (SH2B adaptor protein 2)
Sus scrofa (pig) : SH2B2 (SH2B adaptor protein 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01223,471,477 - 23,501,043 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,473,270 - 23,501,036 (+)Ensembl
Rnor_5.01225,472,225 - 25,501,387 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,544,434 - 21,572,232 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11221,534,314 - 21,562,110 (+)NCBI
Celera1222,198,080 - 22,225,866 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sh2b2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69284
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.