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Gene: Slit1 (slit guidance ligand 1) Rattus norvegicus
Symbol: Slit1
Name: slit guidance ligand 1
Description: Exhibits heparan sulfate proteoglycan binding activity. Involved in brain development; negative regulation of axon extension involved in axon guidance; and spinal cord development. Localizes to extracellular space. Orthologous to human SLIT1 (slit guidance ligand 1); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MEGF4; multiple EGF-like domains protein 4; multiple epidermal growth factor-like domains 4; multiple epidermal growth factor-like domains protein 4; slit (Drosophila) homolog 1; slit homolog 1 (Drosophila); slit homolog 1 protein; slit-1
Homo sapiens (human) : SLIT1 (slit guidance ligand 1)  HGNC  Alliance
Mus musculus (house mouse) : Slit1 (slit guidance ligand 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slit1 (slit guidance ligand 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLIT1 (slit guidance ligand 1)
Canis lupus familiaris (dog) : SLIT1 (slit guidance ligand 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slit1 (slit guidance ligand 1)
Sus scrofa (pig) : SLIT1 (slit guidance ligand 1)
Chlorocebus sabaeus (African green monkey) : SLIT1 (slit guidance ligand 1)
Heterocephalus glaber (naked mole-rat) : Slit1 (slit guidance ligand 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01260,843,481 - 260,992,366 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1260,843,483 - 260,992,366 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01268,298,678 - 268,445,090 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,813,909 - 246,964,408 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11246,928,385 - 247,078,883 (-)NCBI
Celera1236,249,200 - 236,395,640 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slit1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69307
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.