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Gene: Slit2 (slit guidance ligand 2) Rattus norvegicus
Symbol: Slit2
Name: slit guidance ligand 2
Description: Exhibits heparan sulfate proteoglycan binding activity. Involved in central nervous system development; negative regulation of response to external stimulus; and response to nutrient levels. Localizes to plasma membrane. Biomarker of anti-basement membrane glomerulonephritis. Orthologous to human SLIT2 (slit guidance ligand 2); PARTICIPATES IN glypican signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: slit (Drosophila) homolog 2; slit homolog 2 (Drosophila); slit homolog 2 protein; slit-2
Homo sapiens (human) : SLIT2 (slit guidance ligand 2)  HGNC  Alliance
Mus musculus (house mouse) : Slit2 (slit guidance ligand 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slit2 (slit guidance ligand 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLIT2 (slit guidance ligand 2)
Canis lupus familiaris (dog) : SLIT2 (slit guidance ligand 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slit2 (slit guidance ligand 2)
Sus scrofa (pig) : SLIT2 (slit guidance ligand 2)
Chlorocebus sabaeus (African green monkey) : SLIT2 (slit guidance ligand 2)
Heterocephalus glaber (naked mole-rat) : Slit2 (slit guidance ligand 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01466,831,848 - 67,171,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1466,831,848 - 67,170,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01466,864,065 - 67,202,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41467,546,283 - 67,891,840 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11467,624,799 - 67,894,206 (-)NCBI
Celera1461,665,582 - 62,001,006 (-)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slit2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69310
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.