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Gene: Irs2 (insulin receptor substrate 2) Rattus norvegicus
Symbol: Irs2
Name: insulin receptor substrate 2
Description: Exhibits several functions, including 14-3-3 protein binding activity; insulin receptor binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in cellular response to glucose stimulus and insulin receptor signaling pathway. Predicted to localize to cytosol; plasma membrane; and protein-containing complex. Biomarker of non-alcoholic fatty liver disease and osteoporosis. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IRS2 (insulin receptor substrate 2); PARTICIPATES IN insulin signaling pathway; erythropoietin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: 4PS; IRS-2; LOC207125; similar to aldolase; tyrosine kinase substrate
Homo sapiens (human) : IRS2 (insulin receptor substrate 2)  HGNC  Alliance
Mus musculus (house mouse) : Irs2 (insulin receptor substrate 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irs2 (insulin receptor substrate 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IRS2 (insulin receptor substrate 2)
Canis lupus familiaris (dog) : IRS2 (insulin receptor substrate 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irs2 (insulin receptor substrate 2)
Sus scrofa (pig) : IRS2 (insulin receptor substrate 2)
Chlorocebus sabaeus (African green monkey) : IRS2 (insulin receptor substrate 2)
Heterocephalus glaber (naked mole-rat) : Irs2 (insulin receptor substrate 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01683,824,515 - 83,848,569 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,824,430 - 83,848,684 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01683,287,185 - 83,311,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41683,379,987 - 83,404,220 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11683,367,312 - 83,368,308 (+)NCBI
Celera1676,286,571 - 76,310,806 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Irs2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69316
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.