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Gene: Nkx6-1 (NK6 homeobox 1) Rattus norvegicus
Symbol: Nkx6-1
Name: NK6 homeobox 1
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including positive regulation of insulin secretion; type B pancreatic cell development; and type B pancreatic cell proliferation. Localizes to nucleus. Orthologous to human NKX6-1 (NK6 homeobox 1); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide.
Type: protein-coding
Also known as: homeobox protein NK-6 homolog A; homeobox protein Nkx-6.1; NK homeobox (Drosophila), family 6, A; NK homeobox, family 6, A; NK6 transcription factor homolog A; NK6 transcription factor homolog A (Drosophila); NK6 transcription factor related locus 1; NK6 transcription factor related locus 1 (Drosophila); NK6 transcription factor related, locus 1; NK6 transcription factor related, locus 1 (Drosophila); Nkx6.1; Nkx61; Nkx6a
Homo sapiens (human) : NKX6-1 (NK6 homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : Nkx6-1 (NK6 homeobox 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx6-1 (NK6 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX6-1 (NK6 homeobox 1)
Canis lupus familiaris (dog) : NKX6-1 (NK6 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx6-1 (NK6 homeobox 1)
Sus scrofa (pig) : NKX6-1 (NK6 homeobox 1)
Chlorocebus sabaeus (African green monkey) : NKX6-1 (NK6 homeobox 1)
Heterocephalus glaber (naked mole-rat) : Nkx6-1 (NK6 homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0149,555,264 - 9,562,197 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl149,555,264 - 9,562,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0149,516,942 - 9,523,875 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4149,214,743 - 9,221,676 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1149,214,742 - 9,221,668 (+)NCBI
Celera148,087,941 - 8,094,874 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nkx6-1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69318
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.