Gene: Cyp11a1 (cytochrome P450, family 11, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Description: Exhibits cholesterol binding activity and cholesterol monooxygenase (side-chain-cleaving) activity; involved in several processes, including animal organ development, cellular response to cytokine stimulus, and cellular response to growth factor stimulus; localizes to the mitochondrial crista and perikaryon; biomarker of several diseases, including glucose metabolism disease (multiple), hypertension, hypogonadism, nephrosis, and sciatic neuropathy; orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1); PARTICIPATES IN 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; 21-alpha-hydroxylase deficiency pathway; INTERACTS WITH (+)-pilocarpine; (-)-citrinin; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cholesterol desmolase; cholesterol side-chain cleavage cytochrome P450; cholesterol side-chain cleavage enzyme; cholesterol side-chain cleavage enzyme, mitochondrial; Cyp11a; Cypxia1; cytochrome P450 11a cholesterol side chain cleavage; cytochrome P450 11A1; cytochrome P450 family 11 subfamily a; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; cytochrome P450(scc); cytochrome P450, 11a, cholesterol side; cytochrome P450, subfamily 11A; P450(scc); P450scc
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0862,798,317 - 62,809,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0862,525,349 - 62,585,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4861,793,976 - 61,805,308 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1861,812,986 - 61,824,536 (+)NCBI
Celera857,887,124 - 57,898,655 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cyp11a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69325
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.