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Gene: Mapt (microtubule-associated protein tau) Rattus norvegicus
Symbol: Mapt
Name: microtubule-associated protein tau
Description: Exhibits several functions, including Hsp90 protein binding activity; chaperone binding activity; and enzyme binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; nervous system development; and positive regulation of long-term synaptic depression. Localizes to several cellular components, including axon; cytoplasmic side of plasma membrane; and neuronal cell body. Predicted to colocalize with membrane. Used to study cerebrovascular disease (multiple); cognitive disorder (multiple); epilepsy; obesity; and tauopathy (multiple). Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau); PARTICIPATES IN Reelin signaling pathway; Alzheimer's disease pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC156663; Mtapt; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; pTau; RNPTAU; Tau; Tau microtubule-associated protein
Homo sapiens (human) : MAPT (microtubule associated protein tau)  HGNC  Alliance
Mus musculus (house mouse) : Mapt (microtubule-associated protein tau)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapt (microtubule associated protein tau)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPT (microtubule associated protein tau)
Canis lupus familiaris (dog) : MAPT (microtubule associated protein tau)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapt (microtubule associated protein tau)
Sus scrofa (pig) : MAPT (microtubule associated protein tau)
Chlorocebus sabaeus (African green monkey) : MAPT (microtubule associated protein tau)
Heterocephalus glaber (naked mole-rat) : Mapt (microtubule associated protein tau)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01092,289,002 - 92,386,517 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,288,910 - 92,386,517 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01092,050,754 - 92,147,840 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41093,411,098 - 93,508,762 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11093,425,375 - 93,523,128 (+)NCBI
Celera1087,832,730 - 87,930,191 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mapt
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 69329
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.